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sparsentan will decrease the level or impact of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and minimizes efficacy connected to these substrates.modafinil will decrease the extent or result of norgestrel by impacting hepatic/intestinal enzym